Publications

Schneider KH, Oberoi G, Unger E, Janjic K, Rohringer S, Heber S, Agis H, Schedle A, Kiss H, Podesser BK, Windhager R, Toegel S*, Moscato F. Medical 3D printing with polyjet technology: Effect of material type and printing orientation on printability, surface structure and cytotoxicity. 3D Print Med 2023;9:27. doi: 10.1186/s41205-023-00190-y. (view article).

Despicht C, Munkboel CH, Chou HN, Ertl P, Rothbauer M, Kutter JP, Styrishave B, Kretschmann A. Towards a microfluidic H295R steroidogenesis assay-biocompatibility study and steroid detection on a thiol-ene-based chip. Anal Bioanal Chem. 2023;415(22):5421-5436. doi: 10.1007/s00216-023-04816-2. (view article)

Matsuoka K, Bakiri L, Bilban M, Toegel S, Haschemi A, Yuan H, Kasper M, Windhager R, Wagner EF. Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis. Ann Rheum Dis 2023;82(9):1227-1239. doi: 10.1136/ard-2023-224002. (view article)

Steinecker-Frohnwieser B, Lohberger B, Toegel S, Windhager R, Glanz V, Kratschmann C, Leithner A, Weigl L. Activation of the mechanosensitive ion channels Piezo1 and TRPV4 in primary human healthy and osteoarthritic chondrocytes exhibits ion channel crosstalk and modulates gene expression. Int J Mol Sci. 2023;24(9):7868. doi: 10.3390/ijms24097868. (view article)

Stuetz H, Reihs EI, Neuhaus W, Pflüger M, Hundsberger H, Ertl P, Resch C, Bauer G, Povoden G, Rothbauer M. The Cultivation Modality and Barrier Maturity Modulate the Toxicity of Industrial Zinc Oxide and Titanium Dioxide Nanoparticles on Nasal, Buccal, Bronchial, and Alveolar Mucosa Cell-Derived Barrier Models. Int J Mol Sci. 2023;24(6):5634. doi: 10.3390/ijms24065634. (view article)
 
Summer S, Kocsis A, Reihs EI, Rothbauer M, Lonhus K, Stys D, Ertl P, Fischer MB. Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives. Heliyon. 2023 Jan 18;9(1):e12987. doi: 10.1016/j.heliyon.2023.e12987. (view article)
 
Ferreira DA, Conde JP, Rothbauer M, Ertl P, Granja PL, Oliveira C. Bioinspired human stomach-on-a-chip with in vivo like function and architecture. Lab Chip. 2023 Jan 31;23(3):495-510. doi: 10.1039/d2lc01132h. (view article)

Manning JC, Baldoneschi V, Romero-Hernández LL, Pichler KM, García Caballero G, André S, Kutzner TJ, Ludwig AK, Zullo V, Richichi B, Windhager R, Kaltner H, Toegel S, Gabius HJ, Murphy PV, Nativi C. Targeting osteoarthritis-associated galectins and an induced effector class by a ditopic bifunctional reagent: impact of its glycan part on binding measured in the tissue context. Bioorg Med Chem 2022;75:117068. doi: 10.1016/j.bmc.2022.117068. (view article)

Gabius HJ, Cudic M, Diercks T, Kaltner H, Kopitz J, Mayo KH, Murphy PV, Oscarson S, Roy R, Schedlbauer A, Toegel S, Romero A. What is the Sugar Code? Chembiochem 2022;23(13):e202100327. doi: 10.1002/cbic.202100327. (view article)

Rothbauer M, Reihs EI, Fischer A, Windhager R, Jenner F, Toegel S. A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis. Front Bioeng Biotechnol, 2022. doi: 10.3389/fbioe.2022.886360. (view article)

Pichler K, Fischer A, Alphonsus J, Chiari C, Schmidt S, Kenn M, Schreiner W, Weinmann D, Rothbauer M, Windhager R, Gabius HJ, Toegel S. Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in chondrocytes in vitro.Histochem Cell Biol, 2022 Feb;157(2):139-151.  doi: 10.1007/s00418-021-02053-1. (view article) 

Hashemzadeh H, Kelkawi AHA, Allahverdi A, Rothbauer M, Ertl P, Naderi-Manesh H. Fingerprinting Metabolic Activity and Tissue Integrity of 3D Lung Cancer Spheroids under Gold Nanowire Treatment. Cells, 2022 Jan 29;11(3):478. doi: 10.3390/cells11030478. (view article) 

Hager B, Schreiner MM, Walzer SM, Hirtler L, Mlynarik V, Berg A, Deligianni X, Bieri O, Windhager R, Trattnig S, Juras V. Transverse Relaxation Anisotropy of the Achilles and Patellar Tendon Studied by MR Microscopy. J Magn Reson Imaging, 2022. doi: 10.1002/jmri.28095. (view article)

Rothbauer M, Eilenberger C, Spitz S, Bachmann BEM, Kratz SRA, Reihs EI, Windhager R, Toegel S, Ertl P. Recent Advances in Additive Manufacturing and 3D Bioprinting for Organs-On-A-Chip and Microphysiological Systems. Front Bioeng Biotechnol, 2022;10:837087. doi: 10.3389/fbioe.2022.837087. (view article)

Naksuriya O, Daowtak K, Tima S, Okonogi S, Mueller M, Toegel S, Khonkarn R. Hydrolysis Flavonoids from Crytosperma johnstonii with Superior Antioxidant, Anti-proliferative and Anti-inflammatory Potential for Cancer Prevention. Molecules 2022, 27(10), 3226. doi: 10.3390/molecules27103226. (view article)

Eilenberger C, Rothbauer M, Brandauer K, Spitz S, Ehmoser EK, Küpcü S, Ertl P. Screening for Best Neuronal-Glial Differentiation Protocols of Neuralizing Agents Using a Multi-Sized Microfluidic Embryoid Body Array. Pharmaceutics. 2022;14(2):339. doi: 10.3390/pharmaceutics14020339. (view article)

Walzer SM, Toegel S, Chiari C, Farr S, Rinner B, Weinberg AM, Weinmann D, Fischer MB, Windhager R. A 3-Dimensional In Vitro Model of Zonally Organized Extracellular Matrix. Cartilage, 2021;13(2_suppl):336S-345S. doi: 10.1177/1947603519865320. doi:10.1177/1947603519865320. (view article)

Khodayari Bavil A , Sticker D , Rothbauer M , Ertl P , Kim J . A microfluidic microparticle-labeled impedance sensor array for enhancing immunoassay sensitivity. Analyst. 2021;146(10):3289-3298. doi: 10.1039/d0an02081h. (view article)

Bhaskara V, Leal MT, Seigner J, Friedrich T, Kreidl E, Gadermaier E, Tesarz M, Rogalli A, Stangl L, Wallwitz J, Hammel K, Rothbauer M, Moll H, Ertl P, Hahn R, Himmler G, Bauer A, Casanova E. Efficient production of recombinant secretory IgA against Clostridium difficile toxins in CHO-K1 cells. J Biotechnol. 2021;331:1-13. doi: 10.1016/j.jbiotec.2021.02.013. (view article)

Eilenberger C, Selinger F, Rothbauer M, Lin Y, Limbeck A, Schädl B, Grillari J, Kavok NS, Klochkov VK, Malyukin YV, Margitich V, Ertl P. Cytotoxicity, Retention, and Anti-inflammatory Effects of a CeO2 Nanoparticle-Based Supramolecular Complex in a 3D Liver Cell Culture Model. ACS Pharmacol Transl Sci. 2020;4(1):101-106. doi: 10.1021/acsptsci.0c00170. eCollection 2021 Feb 12. (view article)

Zirath H, Spitz S, Roth D, Schellhorn T, Rothbauer M, Müller B, Walch M, Kaur J, Wörle A, Kohl Y, Mayr T, Ertl P. Bridging the academic-industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology. Lab Chip. 2021;21(21):4237-4248. doi: 10.1039/d1lc00528f. (view article)

Rothbauer M, Byrne R, Schobesberger S, Olmos Calvo I, Fischer A, Reihs E, Spitz S, Bachmann B, Sevelda F, Holinka J, Holnthoner W, Redl H, Toegel S, Windhager R, Kiener H, Ertl P. Establishment of a human three-dimensional chip-based chondro-synovial co-culture joint model for reciprocal cross-talk studies in arthritis research. Lab Chip 2021;21(21):4128-4143. doi: 10.1039/d1lc00130b. (view article)

Trummer M, Galardon E, Fischer A, Toegel S, Mayer B, Steiner G, Kloesch B. Characterization of the Inducible and Slow-Releasing Hydrogen Sulfide and Persulfide Donor P*: Insights into Hydrogen Sulfide Signaling. Antioxidants 2021;10(7):1049. doi: 10.3390/antiox10071049. (view article)

Shabestani Monfared G, Ertl P, Rothbauer M. Microfluidic and Lab-on-a-Chip Systems for Cutaneous Wound Healing Studies. Pharmaceutics2021;13(6):793. doi: 10.3390/pharmaceutics13060793. (view article)

Hashemzadeh H, Shojaeilangari S, Allahverdi A, Rothbauer M, Ertl P, Naderi-Manesh H. A combined microfluidic deep learning approach for lung cancer cell high throughput screening toward automatic cancer screening applications. Sci Rep. 2021;11(1):9804. doi: 10.1038/s41598-021-89352-8. (view article)

Fuehrer J, Pichler KM, Fischer A, Giurea A, Weinmann D, Altmann F, Windhager R, Gabius HJ, Toegel S. N-Glycan profiling of chondrocytes and fibroblast-like synoviocytes: Towards functional glycomics in osteoarthritis. Proteomics Clin Appl, 2021 Feb 13;e2000057. doi: 10.1002/prca.202000057. (view article)

Rothbauer M, Bachmann BEM, Eilenberger C, Kratz SRA, Spitz S, Höll G, Ertl P. A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status Report on Progress in Toxicology and Pharmacology. Micromachines 2021;12(5):470. doi: 10.3390/mi12050470. (view article)

Eilenberger C, Rothbauer M, Selinger F, Gerhartl A, Jordan C, Harasek M, Schädl B, Grillari J, Weghuber J, Neuhaus W, Küpcü S, Ertl P. A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood-Brain Barrier Transport Properties. Adv Sci. 2021;8(11):e2004856. doi: 10.1002/advs.202004856. (view article)

Pichler KM, Weinmann D, Schmidt S, Kubista B, Lass R, Martelanz L, Alphonsus J, Windhager R, Gabius HJ, Toegel S. The Dysregulated Galectin Network activates NF-kB to induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes. Calcif Tiss Int, 2021, 108(3):377-390. doi: 10.1007/s00223-020-00774-4. (view article)

Ferreira DA, Rothbauer M, Conde JP, Ertl P, Oliveira C, Granja PL. A Fast Alternative to Soft Lithography for the Fabrication of Organ-on-a-Chip Elastomeric-Based Devices and Microactuators. Adv Sci. 2021;8(8):2003273. doi: 10.1002/advs.202003273. (view article)

Senderek J, Lassuthova P, Kabzińska D, Abreu L, Baets J, Beetz C, Braathen GJ, Brenner D, Dalton J, Dankwa L, Deconinck T, De Jonghe P, Dräger B, Eggermann K, Ellis M, Fischer C, Stojkovic T, Herrmann DN, Horvath R, Høyer H, Iglseder S, Kennerson M, Kinslechner K, Kohler JN, Kurth I, Laing NG, Lamont PJ, Löscher W, Ludolph A, Marques W Jr, Nicholson G, Ong R, Petri S, Ravenscroft G, Rebelo A, Ricci G, Rudnik-Schöneborn S, Schirmacher A, Schlotter-Weigel B, Schoels L, Schüle R, Synofzik M, Francou B, Strom TM, Wagner J, Walk D, Wanschitz J, Weinmann D, Weishaupt J, Wiessner M, Windhager R, Young P, Züchner S, Toegel S, Seeman P, Kochański A, Auer-Grumbach M. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. Neurology 2020, 95(24):e3163-e3179. doi: 10.1212/WNL.0000000000011132. (view article)

Schinhan M, Toegel S, Weinmann D, Schneider E, Chiari C, Gruber M, Nehrer S, Windhager R. Biological Regeneration of Articular Cartilage in an Early Stage of Compartmentalized Osteoarthritis: 12-Month Results. Am J Sports Med. 2020;48(6):1338–1346. doi: 10.1177/0363546520906411. (view article)

Elshamly M, Toegel S, Windhager R, Grohs JG. Long-term impact of sagittal malalignment on hardware after posterior fixation of the thoracolumbar spine: a retrospective study. BMC Musculoskelet Disord. 2020;21:387. doi: 10.1186/s12891-020-03405-z. (view article)

Rothbauer M, Ertl P. Emerging Biosensor Trends in Organ-on-a-Chip.Adv Biochem Eng Biotechnol. 2020, in press. doi: 10.1007/10_2020_129. (view article)

Kratz SRA,  Bachmann B,  Spitz S,  Höll G,  Eilenberger C,  Goeritz H,  Ertl P,  Rothbauer M. A compression transmission device for the evaluation of bonding strength of biocompatible microfluidic and biochip materials and systems. Scientific Reports. 2020;10:1400. doi: 10.1038/s41598-020-58373-0 (view article)

Shabestani Monfared G, Ertl P, Rothbauer M. An on-chip wound healing assay fabricated by xurography for evaluation of dermal fibroblast cell migration and wound closure. Scientific Reports 2020 Oct 1;10(1):16192. doi: 10.1038/s41598-020-73055-7. (view article)

Rothbauer M, Höll G, Eilenberger C, Kratz SRA, Farooq B, Schuller P, Olmos Calvo I, Byrne RA, Meyer B, Niederreiter B, Küpcü S, Sevelda F, Holinka J, Hayden O, Tedde SF, Kiener HP, Ertl P. Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing.  Lab Chip. 2020 Apr 21;20(8):1461-1471. doi: 10.1039/c9lc01097a. (view article)

Benca E, Listabarth S, Flock FKJ, Pablik E, Fischer C, Walzer SM, Dorotka R, Windhager R, Ziai P. Analysis of Running-Related Injuries: The Vienna Study. J Clin Med, 2020;9(2):438. doi: 10.3390/jcm9020438. (view article)

Elshamly M1#, Kinslechner K#, Grohs JG, Weinmann D, Walzer SM, Windhager R, Gabius HJ, Toegel S. Galectins-1 and -3 in Human Intervertebral Disc Degeneration: Non-uniform Distribution Profiles and Activation of Disease Markers Involving NF-kB by Galectin-1. J Orthop Res. 2019;37(10):2204-2216. doi: 10.1002/jor.24351. (#contributed equally) (view article)

Hager B, Walzer SM, Deligianni X, Bieri O, Berg A, Schreiner MM, Zalaudek M, Windhager R, Trattnig S, Juras V. Orientation dependence and decay characteristics of T2 * relaxation in the human meniscus studied with 7 Tesla MR microscopy and compared to histology. Magn Reson Med. 2019;81(2):921-933. doi: 10.1002/mrm.27443. (view article)

Weinmann D, Kenn M, Schmidt S, Schmidt K, Walzer SM, Kubista B, Windhager R, Schreiner W, Toegel S^#,*, Gabius HJ^#. Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3. Cell Mol Life Sci. 2018;75(22):4187–4205. doi: 10.1007/s00018-018-2856-2. (view article)

Weinmann D, Mueller M, Walzer SM, Hobusch GM, Lass R, Gahleitner C, Viernstein H, Windhager R, Toegel S. Brazilin blocks catabolic processes in human osteoarthritic chondrocytes via inhibition of NFKB1/p50. J Orthop Res. 2018;36(9):2431-2438. doi: 10.1002/jor.24013. (view article)

Toegel S. Osteoarthritis biology. In: Principles of Bone and Joint Research. Editor: Pietschmann P. Springer, 2017. ISBN: 978-3-319-58954-1. DOI: 10.1007/978-3-319-58955-8. e-book ISBN: 978-3-319-58955-8. (view textbook)

Kaltner H, Toegel S, Caballero GG, Manning JC, Ledeen RW, Gabius HJ. Galectins: their network and roles in immunity/tumor growth control. Histochem Cell Biol. 2017;147:239-256. (view article) 

Chiari C, Walzer S, Stelzeneder D, Schreiner M, Windhager R. Therapeutic utilization of stem cells in orthopedics. Orthopade 2017;46(12):1077-1090. doi: 10.1007/s00132-017-3475-6. (view article)

Weinmann D, Schlangen K, André S, Schmidt S, Walzer SM, Kubista B, Windhager R, Toegel S*^#, Gabius HJ^#. Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis. Sci. Rep.2016;6:39112. (view article) 

Auer-Grumbach M, Toegel S, Schabhüttl M, Weinmann D, Chiari C, Bennett DL, Beetz C, Klein D, Andersen PM, Böhme I, Fink-Puches R, Gonzalez M, Harms MB, Motley W, Reilly MM, Renner W, Rudnik-Schöneborn S, Schlotter-Weigel B, Themistocleous AC, Weishaupt JH, Ludolph AC, Wieland T, Tao F, Abreu L, Windhager R, Zitzelsberger M, Strom TM, Walther T, Scherer SS, Züchner S, Martini R, Senderek J. Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. Am. J.  Hum. Genet. 2016;99(3):607–23. (view article) 

Toegel S*, Weinmann D, André S, Walzer SM, Bilban M, Schmidt S, Chiari C, Windhager R, Krall C, Bennani-Baiti IM, Gabius HJ. Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB-Regulated Gene Network. J. Immunol. 2016;196:1910-1921. (view article)

Mueller M, Weinmann D, Toegel S, Holzer W, Unger FM, Viernstein H. Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes. Food Funct. 2016;7:1671–1679. (view article)

Walzer SM, Weinmann D, Toegel S*. Medical Plant Extracts for Treating Knee Osteoarthritis: a Snapshot of Recent Clinical Trials and Their Biological Background. Curr Rheumatol Rep 2015;17:1-9. (view article) 

Bennani-Baiti B, Toegel S, Viernstein H, Urban E, Noe CR, Bennani-Baiti IM. Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells. PLoS One 2015;10(9):e0139101. (view article)

Zbýň Š, Brix MO, Juras V, Domayer SE, Walzer SM, Mlynarik V, Apprich S, Buckenmaier K, Windhager R, Trattnig S. Sodium magnetic resonance imaging of ankle joint in cadaver specimens, volunteers, and patients after different cartilage repair techniques at 7 T: initial results. Invest Radiol 2015;50(4):246-54. (view article)

Walzer SM, Cetin E, Grübl-Barabas R, Sulzbacher I, Rueger B, Girsch W, Toegel S, Windhager R, Fischer MB. Vascularization of primary and secondary ossification centres in the human growth plate. BMC Dev Biol2014;14:36. (view article)

Hobusch G and Toegel S. Arthrose: Auf dem Weg zu einem differenziert wahrgenommenen Krankheitsbild. JATROS Orthopädie & Rheumatologie2014; 4:48-50.

Toegel S* and Hobusch G. Arthrose: Der komplexe Aufbau eines grundlagenwissenschaftlichen Fundaments. JATROS Orthopädie & Rheumatologie 2014;5:40-42.

Toegel S*, Bieder D, André S, Kayser K, Walzer SM, Hobusch G, Windhager R, Gabius HJ. Human osteoarthritic knee cartilage: fingerprinting of adhesion/growth-regulatory galectins in vitro and in situ indicates differential upregulation in severe degeneration. Histochem Cell Biol 2014;142:373-88. (view article)

Toegel S and Windhager R. Glykobiologie: Die „süße Seite“ der Arthroseforschung. JATROS Orthopädie & Rheumatologie 2014;1:10-11.

Novakova I, Subileau E-A, Toegel S, Gruber D, Lachmann B, Urban E, Chesne C, Noe CR, Neuhaus W. Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models.PLoS ONE 2014;9:e86806.(view article)

Toegel S*, Bieder D, André S, Altmann F, Walzer S, Kaltner H, Hofstaetter JG, Windhager R, Gabius HJ. Glycophenotyping of osteoarthritic cartilage and chondrocytes by RT-qPCR, mass spectrometry, histochemistry with plant/human lectins and lectin localization with a glycoprotein. Arthritis Res Ther 2013;15:R147. (view article)

Bustin SA, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley G, Wittwer CT, Schjerling P, Day PJ, Abreu M, Aguado B, Beaulieu JF, Beckers A, Bogaert S, Browne JA, Carrasco-Ramiro F, Ceelen L, Ciborowski K, Cornillie P, Coulon S, Cuypers A, De Brouwer S, De Ceuninck L, De Craene J, De Naeyer H, De Spiegelaere W, Deckers K, Dheedene A, Durinck K, Ferreira-Teixeira M, Fieuw A, Gallup JM, Gonzalo-Flores S, Goossens K, Heindryckx F, Herring E, Hoenicka H, Icardi L, Jaggi R, Javad F, Karampelias M, Kibenge F, Kibenge M, Kumps C, Lambertz I, Lammens T, Markey A, Messiaen P, Mets E, Morais S, Mudarra-Rubio A, Nakiwala J, Nelis H, Olsvik PA, Pérez-Novo C, Plusquin M, Remans T, Rihani A, Rodrigues-Santos P, Rondou P, Sanders R, Schmidt-Bleek K, Skovgaard K, Smeets K, Tabera L, Toegel S, Van Acker T, Van den Broeck W, Van der Meulen J, Van Gele M, Van Peer G, Van Poucke M, Van Roy N, Vergult S, Wauman J, Tshuikina-Wiklander M, Willems E, Zaccara S, Zeka F, Vandesompele J. The need for transparency and good practices in the qPCR literature. Nat Methods2013;10:1063-7. (view article)

Glehr M, Fritsch-Breisach M, Lohberger B, Walzer SM, Moazedi-Fuerst F, Rinner B, Gruber G, Graninger W, Leithner A, Windhager R. Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine 2013;20:310-8. (view article)

Salar-Behzadi S, Wu S, Toegel S, Hofrichter M, Altenburger I, Unger FM, Wirth M, Viernstein H. Impact of heat treatment and spray drying on cellular properties and culturability of Bifidobacterium bifidum BB-12. Food Res Int 2013;54:93–101. (view article)