Mission statement
The mission of the Karl Chiari Lab for Orthopaedic Biology is to uncover the molecular and cellular mechanisms driving musculoskeletal diseases and to translate these insights into innovative therapeutic strategies.
Our research is centered on osteoarthritis and related degenerative and inflammatory conditions, with complementary expertise spanning orthopaedic tumors and regenerative approaches. We place particular emphasis on understanding how cellular communication, tissue microenvironment, and biomechanical cues shape disease progression.
A key focus of our work is the role of glycobiology in musculoskeletal tissues, especially the function of galectins and glycan-mediated signaling in cartilage homeostasis and degeneration (Stefan Toegel). In parallel, we develop advanced in vitro models, including microphysiological systems and tissue-engineered platforms, to study disease mechanisms and therapeutic interventions in a controlled and translationally relevant context (Mario Rothbauer).
By integrating molecular biology, bioengineering, and systems-level analysis, we aim to bridge fundamental biology with clinical application. Our multidisciplinary approach combines cell biology, biochemistry, advanced imaging, and organ-on-chip technologies to generate mechanistic insights and accelerate therapeutic innovation.
Beyond research, we are committed to fostering interdisciplinary education and to training the next generation of scientists and clinicians. We actively promote the translation of scientific knowledge into clinical practice and engage with the broader scientific and medical community.