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Arthrose und Geweberegeneration

  1. Universitätsklinik für Orthopädie und Unfallchirurgie
  2. Forschung
  3. Forschungscluster
  4. Arthrose und Geweberegeneration
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Degeneration of joint tissues following aging, overuse, altered biomechanics, or traumatic events rank among the most widespread musculoskeletal disorders, affecting hundreds of millions of people worldwide. Therapeutic options for these conditions are still vastly limited, thus placing an enormous burden on affected patients and health care systems alike. 

The research cluster ‘Osteoarthritis & Tissue regeneration’ brings together the different scientific activities related to this topic that are ongoing at the Department of Orthopedics and Trauma Surgery. It involves basic research as well as translational concepts and clinical studies, thus covering a wide range of methods and techniques such as histology, cell culture, stem cells, osseointegration, glycobiology, 3D (bio)printing, Lab-on-a-chip, biomaterials, biological glues, cartilage repair, bone defects, low level light therapy, automated X-ray analysis, and matrix-associated autologous chondrocyte transplantation (MACT). Members of this cluster are active in academic teaching and as supervisors of master, diploma and PhD theses with the aim to educate and inspire the next generation of researchers.

To get involved in the cluster activities, please contact the cluster coordinator or the principal investigators.

Assoc.Prof. Priv.Doz. Mag. Dr. Stefan Tögel

Coordinator

T: +43 (0)1 40400-40980
F: +43 (0)1 40400-76410
E-Mail: stefan.toegel@meduniwien.ac.at

Principal investigators

 

Important publications

  • Weinmann D, Kenn M, Schmidt S, Schmidt K, Walzer SM, Kubista B, Windhager R, Schreiner W, Toegel S#,*, Gabius HJ#. Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3. Cell Mol Life Sci. 2018;75(22):4187–4205. doi:10.1007/s00018-018-2856-2.
  • Pichler KM, Weinmann D, Schmidt S, Kubista B, Lass R, Martelanz L, Alphonsus J, Windhager R, Gabius HJ, Toegel S. The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes. Calcif Tissue Int. 2021;108(3):377-390. doi:10.1007/s00223-020-00774-4.
  • Chiari C, Grgurevic L, Bordukalo-Niksic T, Oppermann H, Valentinitsch A, Nemecek E, Staats K, Schreiner M, Trost C, Kolb A, Kainberger F, Pehar S, Milosevic M, Martinovic S, Peric M, Sampath TK, Vukicevic S, Windhager R. Recombinant Human BMP6 Applied Within Autologous Blood Coagulum Accelerates Bone Healing: Randomized Controlled Trial in High Tibial Osteotomy Patients. J Bone Miner Res. 2020 Oct;35(10):1893-1903. doi:10.1002/jbmr.4107.
  • Döring K, Rentenberger C, Kolb A, Patsch J, Puchner S, Windhager R, Chiari C. Treatment of benign bone lesions with an injectable biphasic bone substitute. BMC Musculoskelet Disord. 2022;23(1):901. doi:10.1186/s12891-022-05843-3.
  • Schneider C, Dungel P, Priglinger E, Danzer M, Schädl B, Nürnberger S. The impact of photobiomodulation on the chondrogenic potential of adipose-derived stromal/stem cells. J Photochem Photobiol B. 2021;221:112243. doi:10.1016/j.jphotobiol.2021.112243.
  • Fürsatz M, Gerges P, Wolbank S, Nürnberger S. Autonomous spheroid formation by culture plate compartmentation. Biofabrication. 2021;13(3). doi:10.1088/1758-5090/abe186 
  • M Rothbauer, RA Byrne, S Schobesberger, I Olmos Calvo, A Fischer, EI Reihs, S Spitz, B Bachmann, F Sevelda, J Holinka, W Holnthoner, H Redl, S Toegel, Reinhard Windhager, HP Kiener, P Ertl. Establishment of a human three-dimensional chip-based chondro- synovial co-culture joint model for reciprocal crosstalk studies in arthritis research. Lab Chip. 2021;21(21):4128-4143. doi:10.1039/D1LC00130B
  • Rothbauer M, Höll G, Eilenberger C, Kratz SRA, Farooq B, Schuller P, Olmos Calvo I, Byrne RA, Meyer B, Niederreiter B, Küpcü S, Sevelda F, Holinka J, Hayden O, Tedde SF, Kiener HP, Ertl P. Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing. Lab Chip. 2020;20(8):1461-1471. doi:10.1039/c9lc01097a
  • Tiefenboeck TM, Payr S, Bajenov O, Dangl T, Koch T, Komjati M, Sarahrudi K. Different storage times and their effect on the bending load to failure testing of murine bone tissue. Sci Rep. 2020;10(1):17412. doi:10.1038/s41598-020-74498-8.
  • Tiefenboeck TM, Payr S, Bajenov O, Koch T, Komjati M, Sarahrudi K.Effect of two (short-term) storage methods on load to failure testing of murine bone tissue. Sci Rep. 2019;9(1):5961. doi:10.1038/s41598-019-42476-4.
  • Zak L, Albrecht C, Wondrasch B, Widhalm H, Vekszler G, Trattnig S, Marlovits S, Aldrian S. Results 2 Years After Matrix-Associated Autologous Chondrocyte Transplantation Using the Novocart 3D Scaffold: An Analysis of Clinical and Radiological Data. Am J Sports Med. 2014 Jul;42(7):1618-27. doi:10.1177/0363546514532337.
  • Zak L, Aldrian S, Wondrasch B, Albrecht C, Marlovits S. Ability to return to sports 5 years after Matrix-associated autologous chondrocyte transplantation on an average active patient population. Am J Sports Med. 2012;40(12):2815-21. doi:10.1177/0363546512462382.